The story follows young treasure hunter Nathan Drake (Tom Holland), who is recruited by experienced adventurer Victor ‘Sully’ Sullivan (Mark Wahlberg) to find a legendary treasure lost during the Magellan expedition.

During their journey, they must solve puzzles, dodge traps and fight a dangerous rival group led by the ruthless Moncada (Antonio Banderas). As Nathan learns more about his past and his brother's disappearance, he discovers that trust and betrayal go hand in hand in the world of treasure hunting. The film is full of spectacular action, humour and exciting twists.